Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with\r\natherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and,\r\ndiabetes. Remnant lipoproteins become attached to the vascular wall, where they can penetrate intact endothelium causing foam\r\ncell formation. Postprandial remnant lipoproteins can activate circulating leukocytes, upregulate the expression of endothelial\r\nadhesion molecules, facilitate adhesion and migration of inflammatory cells into the subendothelial space, and activate the\r\ncomplement system. Since humans are postprandial most of the day, the continuous generation of remnants after each meal\r\nmay be one of the triggers for the development of atherosclerosis. Modulation of postprandial lipemia by lifestyle changes and\r\npharmacological interventions could result in a further decrease of cardiovascular mortality and morbidity. This paper will provide\r\nan update on current concepts concerning the relationship between postprandial lipemia, inflammation, vascular function, and\r\ntherapeutic options.
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